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Beyond classic bone-marrow suppression and transaminase elevation, four pulmonary-specific and systemic hazards demand particular vigilance in patients with LC: Radiation-like pneumonitis/fibrosis, iron-catalyzed oxidative stress, CD8+ T-cell functional exhaustion and QT-interval prolongation (144)

CLA, or conjugated linoleic acid, is often included in body composition supplements aimed at supporting lean mass retention while dieting

Figure 1 provides design of a transdermal patch according to the present invention

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